Whole brain radiotherapy

Considered the standard of care for intracranial metastases control.

Studies have suggested that with a limited number of lesions, up to four, stereotactic radiosurgery may be efficacious and less toxic alternative.

Associated with significant neurocognitive side effects and decrease in quality of life.

Moderate to severe dementia can occur several months to years after treatment.

WBRT may limit utilization of blood-brain barrier penetrating therapies in future care.

Adding chemo therapy to WBRT shows encouraging responses but with high toxicity rates and unchanged overall survival.

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