Voice signal analysis is an emerging noninvasive diagnostic tool.
Voice signal characteristics may be associated with a number of different pathological entities including; dyslexia, attention deficit/hyperactivity disorder, Parkinson’s disease, other neurologic disorders, and coronary artery disease.
Pitch variability among children with autism spectrum disorder allows classification of such disorders with an 80% accuracy.
Voice features can differentiate paroxysmal coughing from pertussis with 90% success rate.
Voice samples from healthy subjects and patients with heart disease suggested possible distinct voice features in patients with heart disease.
It is hypothesized that systemic inflammatory processes that affect atherosclerosis, chronic kidney disease, cerebrovascular disease, vascular dementia, retinopathy, peripheral artery disease may involve anatomic structures associated with voice production.
Analysis showed that the strongest association between voice and coronary artery disease was a dinner fied one patients were asked to describe an emotional experience.
There is a relationship between mental stress, the adrenergic system and the voice, so that emotional stress changes the human voice, including an increase in fundamental frequency.
There is an association between increase in voice jitter in beta adrenergic receptor blockade with propranolol among healthy men and women.
It is suggested that voice characteristics are an index of underlying stress and adrenergic activity that correlate with coronary artery disease.
Voice is created by three major components: the lungs which provide air to create sound, the larynx which contains the vocal cords and other vital muscles, and the articulators, the tongue, the palate, and the mouth muscles.
Most of the voice creation and control is subconscious.
Nerves involved in voice creation include cranial nerves five, seven, 10, 11, and 12.
The 10th cranial nerve, the Vegas nerve, is closely related to the heart and is important in voice control.
Patient will refractory epilepsy who undergo vagal nerve stimulation have significance voice change.
Changes in the Vegas nerve can cause fluctuation in the heart rate, known as heart rate variability.
Heart rate variability and coronary artery disease are well-established relations.
Voice and coronary disease therefore have a relationship providing a biologic basis for the underlying findings of voice analysis.