Vitamin K epoxide reductase (VKORC1)

Recycles vitamin K epoxide to the reduced form of vitamin K, an essential cofactor in formation of active clotting factors II, VII, IX and X via gamma-glutamyl carboxylation.

The target of coumarone anticoagulants.

Genetic variants exist which alter sensitivity to warfarin.

Presence of polymorphisms require utilizing lower doses of warfarin.

May account for variation in dose requirement of warfarin more than CYP2C9 in some individuals.

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