A short chain fatty acid anticonvulsant.
Inhibits histone deacetylase (HDAC) at antileptic levels.
Response rate in 30% of patients of elderly patients with AML or myelodysplastic syndrome with unfavorable prognostic features.
Exposure of this agent during the first trimester linked to an increased risk of congenital spina bifida and other congenital abnormalities.
Prenatal use is associated with a significant increase risk of autism spectrum disorder and childhood autism (Christensen J et al).
Rarely associated with hyperammonemic encephalopathy..