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Urokinase

Plasminogen activator that promotes invasion and metastases in many malignancies.

55 kilodalton serine protease, cleaves extracellular matrix components including fibronectin, laminin, and Type IV collagen.

Proteolytic efficacy relies on interaction with plasminogen activator inhibitor 1 (PAI-1) and cell surface receptor for urokinase.

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