1.1 million children worldwide become ill with tuberculosis yearly, predominantly in low in middle income countries.
Childhood tuberculosis is identified in the context of acute lower respiratory tract infection or pneumonia.
The most common symptoms of active TB in younger children include:
Fever
Weight loss
Poor growth
Cough
Lymphadenopathy
Chills
The most common symptoms of active TB in older children include:
Cough that lasts longer than 3 weeks
Pain in the chest
Blood in sputum
Weakness
Tiredness
Lymphadenopathy
Weight loss
Decrease in appetite
Fever
Sweating at night
Chills
Difficulties in treating childhood tuberculosis: lack of microbiological confirmation, a long duration of treatment, lack of easy access to palatable pediatric formulations, pill burden, and medication side effects.
In a trial comparing eight weeks of standard treatment with isoniazid, rifampin, and pyrazinamide as a fixed dose formulation with or without ethambutal, all followed by either eight weeks or 16 weeks of isoniazid and rifampin in a fixed dose combination.
For latent TB, several medicine options are available.
Children over 2 years old can be treated with once-weekly medicine for 12 weeks or several months of daily medicine.
For active TB, a child will be given 2 to 4 medicines for 6 months or more.
Active TB can be prevented by having latent TB diagnosed and treated.
TB is diagnosed with a TB skin or blood test, chest X-ray, sputum tests, and possibly other testing or biopsies.