19% of patients with strokes, head injuries or seizures had an elevated troponin T level had an associated poor prognosis.
HIghly sensitive cardiac troponin T assay is detected in almost all patients with heart failure or ischemic heart disease.
In the general population minimally elevated cardiac troponin levels are rare in individuals without a chronic condition such as heart failure, left ventricular hypertrophy, chronic kidney disease, or diabetes mellitus.
HIghly sensitive cardiac troponin T assay detects levels approximately 10 times lower than those detectable with standard testing.
HIghly sensitive cardiac troponin T assay
Cardiac troponin I and cardiac troponin T assays clinically perform comparably.
Cardiac troponin T is more commonly elevated in patients with chronic kidney disease, but with more sensitive cardiac troponin i assays the difference is narrowing.
The cardiac troponin T assays used are less sensitive than many cardiac troponin I assays.
In a longitudinal study of 4221 community dwelling adults age 65 years or older without prior heart failure using a highly sensitive cardiac troponin T assay at baseline and repeated after 2-3 years changes were significantly associated with the incident heart failure and cardiovascular deaths (de Filippi CR et al).
In a study of 3546 individuals age 30-65 measurements using standard and highly sensitive assays for cardiac troponin T levels, the highly sensitive assay was associated with structural heart disease and subsequent risk of all cause mortality (de Lemos et al).
Circulating cardiac troponin T is detectable in approximately 25% of adults aged 30-65 years in a general population, and such levels was associated with cardiac structural abnormalities including LVH, and LV systolic dysfunction.
High sensitive cardiac troponin T is the best baseline prognostic marker for primary amyloidosis.
Elevated cardiac troponin T levels are predictive of short and long-term mortality in patients with acute respiratory conditions.
Minimally elevated cardiac troponin levels in asymptomatic older individuals and in patients with chronic kidney failure are associated with all cause death.
In patients with acute G.I. bleeding cardiac troponin T level elevations are independently associated with long-term but not short-term mortality.
Cardiac troponin T predicts end stage renal disease and all cause death in community dwelling individuals with hypertension.