A topical cream approved for the treatment of acne vulgaris in patients nine years and older.

Tradename Aklief.
A topical retinoid.
Retinoids normalize keratinization and have anti-inflammatory effects.
Topical retinoids are use for first line treatment of acne, either alone or in combination with topical antibiotics  or benzoyl peroxide.
Retinoids bind to the retinoic acid receptor, which has three isoforms: RAR-alpha, RAR-beta, and RAR-gamma.
RAR activates genes that regulate immune modulation, cell differentiation, proliferation, and apoptosis.
It is the only retinoid that is a selective RAR-gamma, the most prevalent RAR form in the skin.
The most common adverse effects are  application site irritation, ad pruritus.

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