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Tremelimumab

Tremelimumab is a monoclonal antibody approved in combination with durvalumab and platinum-based chemotherapy for adult patients with metastatic non-small cell lung cancer (NSCLC).

Tremelimumab combined with durvalumab and platinum-based chemotherapy demonstrated a strong overall survival rate compared with only platinum-based chemotherapy treatment. 

The overall response rate of treatment arm one was 39% compared with the response rate of treatment arm three 24%.

Common adverse reactions, which occurred in over 20% of patients, included nausea, fatigue, decreased appetite, musculoskeletal pain, rash, and diarrhea.

Tremelimumab combined with durvalumab efficacious for hepatic carcinoma.

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