Topoisomerase II inhibitors

Such as anthracyclines are potent antineoplastic drugs used against leukemias, lymphomas, and solid tumors.

Induce formation of stable complex between the enzyme DNA topoisomerase II and DNA, resulting in the introduction of double strand DNA breaks and alterations in replication and transcription that trigger apoptosis and cell death.

Leave a Reply

Your email address will not be published. Required fields are marked *