Trade name Zanaflex.

A centrally acting α2 adrenergic agonist used as a muscle relaxant.

It is used to treat the spasms, cramping, and tightness of muscles due to varying conditions including: multiple sclerosis, ALS, spastic diplegia, back pain, and injuries to the spine or central nervous system.

Additional uses include: migraine, sleep aid, anticonvulsant and for fibromyalgia.

Pregnancy category C.

Oral administration by tablets or capsules.

Bioavailability is about 40%.

Protein binding about 30%.

Metabolism-Liver (CYP1A2, 95%)

Elimination half-life 2.54 hours.

Excretion Urine (60%), feces (20%).

As effective as other antispasmodic drugs and is more tolerable than baclofen and diazepam.

Tizanidine can be very strong even at the 2 mg dose and

May cause hypotension.

Can occasionally cause acute liver failure.

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