Usually develops after infection, sepsis, trauma, stroke or radioactive therapy.
Most patients have signs and symptoms of thyrotoxicosis.
Associated with tachycardia, fever, CNS dysfunction with agitation, irritability, confusion, emotional instability, psychosis, and coma.
Tachyarrhythmias, hypertension and cardiac decompensation may be present.
Because of the poor prognosis of untreated disease, treatment should begin as soon as the diagnosis is suspected and not wait for laboratory confirmation.