Thymidylate synthase

Inhibited by fluoropyrimidines.

A target for 5FU.

Catalyzes the intracellular conversion of deoxyuridylate to deoxythymidylate and is the only de novo source of thymidine in cells.

Essential for DNA synthesis and for limiting cell growth.

Overexpression confers resistance to 5FU in metastatic colorectal cancer.

Increased intratumoral expression of thymidylate synthetase mRNA associated with adverse effect on prognosis with various cancers.

Increased TS expression in tumors is associated with resistance to 5FU and capecitabine.

Increased intratumoral TS in metastatic tumors is indicative of 5FU resistance.

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