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Thromboplastin

Thromboplastin

Thromboplastin or thrombokinase.

A plasma protein aiding blood coagulation through catalyzing the conversion of prothrombin to thrombin.

A complex enzyme that is found in brain, lung, and other tissues and especially in blood platelets and that functions in the conversion of prothrombin to thrombin in the clotting of blood.

Sometimes used as a synonym for the protein tissue factor.

Thromboplastin can activate the extrinsic coagulation pathway.

In the laboratory, a derivative can be created called partial thromboplastin.

The partial thromboplastin is used to measure the intrinsic pathway, the aPTT, or activated partial thromboplastin time.

Thromboplastin is the combination of both phospholipids and tissue factor, both of which are needed in the activation of the extrinsic pathway.

Partial thromboplastin is just phospholipids, and not tissue factor.

Phospholipid is available as an independent reagent or in combination with tissue factor as thromboplastin.

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