Testosterone proprionste

Testosterone propionate is an androgen and anabolic steroid medication which is used mainly in the treatment of low testosterone levels in men.



It is given by injection into muscle usually once every two to three days.



Routes of administration: Intramuscular injection, buccal



US: Schedule III



Pharmacokinetic data






Oral: very low



Intramuscular: very high



Metabolism Liver



Elimination half-life


Intramuscular: 0.8 days 



Excretion Urine



Side effects: symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire.



It is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).



Strongly  androgenic and its moderate anabolic effects, which make it useful for producing masculinization and suitable for androgen replacement therapy.



A testosterone ester and a relatively short-acting prodrug of testosterone.



It is considered to be a natural and bioidentical form of testosterone.



It was the major form of testosterone used in medicine until about 1960.



The introduction of longer-acting testosterone esters like testosterone enanthate, testosterone cypionate, and testosterone undecanoate resulted in testosterone propionate mostly being superseded.



It is rarely used today.



It is used to improve physique and performance.



It is specifically approved for the treatment of hypogonadism in men, breast cancer, low sexual desire, delayed puberty in boys, and menopausal symptoms.



Testosterone propionate is usually in an oil solution for use by intramuscular injection.



Side effects include virilization among others.



It is often a painful injection.



Ot has a relatively short elimination half-life and mean residence time of 2 days and 4 days, respectively.



 Must be administered two to three times per week.



Testosterone propionate is no longer available commercially in the United States except via a compounding pharmacy.



Testosterone propionate, is a schedule III controlled substance in the United States.




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