T(14;18) translocation

t(14;18) translocation is the earliet recurrent event giving rise to a BCL2-IGH fusion.

Originates from bone marrow pre-B cells.

Malignant follicular lymphoma clones are derived from the transformation of germinal center B cells in secondry lynphoid organs.

50-70 percent of healthy individuals have low levels of circulating t(14;18) positive cells, but did not develop follicular lymphoma.

BCL2 expression is necessary but not sufficient to tumor progression.

High t(14;18) frequency and bloody and healthy individuals can be predictive biomarkers for follicular lymphoma, may occur years before diagnosis .(Roulland S et al).

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