Substantial tissue replacement or restoration may be required during surgical interventions for various disease processes, including organ failure, neoplasms, second- and third-degree burns, and necrotizing infections.
Often, repair of these tissues requires external support usually in the form of surgical matrix or mesh.
The primary function of the matrix is to provide non-immunogenic yet structural support.
In some cases, the matrix can go beyond structural support and spur wound healing.
The inability of wound repair to occur in the area of the matrix, has driven the development of biomaterials and cellular therapies targeted to overcome these deficits.
The extracellular environment has an important impact on cellular function and differentiation.
Three dimension fabrication techniques hold the promise of creating new scaffolds that can achieve the desired effect on cellular and tissue function.
Tissue replacement restoration may be required during surgical interventions for organ failure, neoplasms, second and third-degree burns, and necrotizing infections.
Repair of these tissues often requires external support usually in the form of surgical metrics or mesh.
The primary function of the metrics provides a non-immunogenic yet structural support.
Materials can be divided into biologic, purely synthetic, and hybrid materials that have components of biologics and synthetics.