Stevens-Johnson Syndrome

Mucocutaneous disorder usually attributed to a drug exposure or infection.

50% drug induced and 50% caused by infectious causes.

Skin changes of generalized tender erythematosus macules that progress to blisters often preceded by photophobia, upper respiratory symptoms and fever.

Incidence equal in sexes.

Mortality approximately 5%.

Fever common.

Facial involvement and swelling may occur.

Mucous membrane with mouth, lips, conjunctivae and anogenital areas being involved.

Blisters or epidermal detachment may occur over less than 10% of the body surface area.

Affected patients present with blistering erythematous lesions, purpuric macules, atypical target lesions, and hemorrhagic erosions affecting at least two mucosal sites.

Epidermal detachment is limited to less than 10% of body surface area.

When more than 30% of the body surface area is involved the process is classified as toxic epidermal necrolysis.

Corticosteroid use is not a proven efficacious treatment.

Overlaps with toxic epidermal necrosis.

Patients usually have a slow recovery.

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