Simian virus40 (SV40)

Detected in pediatric and adult brain tumors, mesotheliomas, osteosarcomas, bronchopulmonary carcinomas, pituitary tumors, papillary thyroid carcinomas, leukemias and possibly non-Hodgkin’s lymphomas.

A Polyomavirus, double stranded DNA genome.

ERndogenous among rhesus monkeys, but is also widespread among humans.

Produces two proteins once inside the host associated with oncogenesis, large and small t antigens.

The large t antigen. Tag, is a 90 kD protein able the induce structural and numerical chromosomal abnormalities.

Tag induces IGF expression, can inhibit p53, and the pRB family and can stimulate cell proliferation.

Small t-antigen is a 17-KD protein found in cytoplasm of infected cells and it inhibits cellular phosphatase kinase and AP-1 activity.

Small tag t-antigen works with Tag to bind and inhibit p53 and pRB.

Small and large tag antigens combine to induce Notch-1 and telomerase activity required for malignant transformation.

Sequences of the virus present in 60% of mesotheliomas.

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