Sex related differences in myocardial infarction

A total of 6,720,639 weighted hospitalizations for MI (79.8% NSTEMI, and 20.2% STEMI) were included in a study: The incidence rate of hospitalizations for MI was lower in women than men across all age groups. 

The annual mortality rate and absolute number of individuals living with and dying of cardiovascular disease is remained greater among women than men over the last three decades.

Myocardial infarction is a key indicator of the burden of cardiovascular disease and serves as a bellwether in examining six differences in cardiovascular disease.

The excess risk of death observed in women with MI is explained by differences in baseline characteristics and management.

Some studies suggest that only young women have a higher risk of death after MI, suggesting sex specific pathophysiological differences, particularly at younger ages.

Women were less likely than men to undergo coronary angiography, revascularization, or to use circulatory-support devices. 


These differences were consistent across all age groups.


Women are older and have more comorbidity at the time of the first MI.

Compared with men, women have lower incidence of MI and less likelihood of undergoing invasive treatment regardless of age.


The negative impact of female sex on most outcomes was most pronounced in young and middle-aged women.

Women experience higher risk of recurrent MI than men.


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