Seborrheic keratoses


One of the most common benign neoplasms in adults usually appearing after the age of 30 years in genetically susceptible persons.

Continually develop throughout an individual’s lifespan.

Non-cancerous lesion.

Often appear in middle-aged and older adults.

Some individuals have one lesion, but most people have multiple lesions.

Most often seborrheic keratoses start as small, rough skin bumps that thicken and are wart-like.

Most lesions are tan or brown, but may be white or black, and can appear on all skin sites, except palms ans soles.

Occurs in about 83 million people in the US, primarily middle-aged and older adults.

Can look like warts, moles, actinic keratoses, and skin cancer.

Appear like wax droppings.

Range in size from a fraction of an inch to larger than a half-dollar.

Not associated with pain.

Some lesions may itch.

Lesions first appear in middle age or later.

Family members commonly have seborrheic keratoses.

May appear during pregnancy or following estrogen replacement therapy.

Rare in children.

Most lesions are left untreated or treated without histological analysis.

They generally do not require treatment, but patients want them removed for cosmetic reasons or because they have become irritated.

Differential diagnosis includes actinic keratoses, viral warts, solar lentigo and melanoma.

Melanoma prevalence in histological lesions submitted as seborrheic keratosis 0.3-0.66%

Clinical diagnosis usually establishes the dignosis.

Usually left alone without treatment.

Can be removed by scalpel, curretage, or shaving, liquid nitrogen, electrosurgery and curettage.

Cryotherapy with liquid nitrogen is the most common method for removing such lesions.

Cryo-therapy can cause mild pain, scarring, hyper or hypo pigmentation.

Following treatment most removed seborrheic keratoses do not return.

Hydrogen peroxide 40% topical solution is approved for the treatment of raised seborrheic keratoses in adults.

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