Schlemm’s canal


A circular lymphatic-like vessel in the eye that collects aqueous humor from the anterior chamber and delivers it into the episcleral blood vessels via aqueous veins.

It is essentially an endothelium-lined tube.

It resembles of a lymphatic vessel, and shares several structural and functional features reminiscent of the lymphatic vasculature.

Nearest to the aqueous humor, it is covered by the trabecular meshwork.

The region of the trabecular meshwork makes the greatest contribution to outflow resistance of the aqueous humor.

The Schlemm’s canal is never filled with blood in physiological settings as it does not receive arterial blood circulation.

It is sensitive to the inhibition of lymphangiogenic growth factors, and the administration of the lymphangiogenic growth factor VEGFC enlarged the Schlemm’s canal, which was associated with a reduction in intraocular pressure.

Canaloplasty is a procedure designed to enhance and restore the eye’s natural drainage system to provide sustained reduction of intraocular pressure. inside the eye is relieved.