S-adenosyl-L-methionine (SAMe)


S-adenosyl-L-methionine (SAMe) is a compound found naturally in the body. 

SAMe helps produce and regulate hormones and maintain cell membranes.

A synthetic version of SAMe is available as a dietary supplement in the U.S. 

SAMe can be taken orally, through a muscular injection or by IV. 

People generally use SAMe to treat depression, osteoarthritis and liver disease. 

SAMe can also interact with antidepressant medications.

SAMe appears to be safe and effective in treating depression and osteoarthritis. 

Side effects from SAMe are usually mild.

Digestive problems, such as nausea, diarrhea or constipation

Mild insomnia





People who have a weakened immune system may be at increased risk of an infection caused by pneumocystis, as SAMe may boost this microorganism’s growth.

Possible drug interactions include:

Antidepressants, antipsychotics, amphetamines, dextromethorphan and other drugs and supplements that increase levels of serotonin. 

SAMe might reduce the effectiveness of levodopaused to treat Parkinson’s disease.

Taking SAMe with meperidine or tramadol could increase the risk of serotonin syndrome.

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