A normal component of bone marrow that is detectable by silver staining methods in 73-81% of healthy individuals.

Increased reticulin is associated with a number of benign and malignant processes.

Thrombopoietic growth factor therapy can induce reticulin fibrosis in the bone marrow.

Reticulin fibrosis has been observed in trials of romiplostim and eltrombopag.

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