Renal impairment

Increases the likelihood of antibiotic drug toxicity, as well as toxicity to amantidine, nonsteroidal anti-inflammatory drugs, angiotensin-converting enzyme inhibitors and digoxin.

Prevalence of elevated serum creatinine levels is 8.9% among men and 8% among women in community-based adults.

Renal insufficiency is a strong predictor of adverse outcomes in patients with various cardiovascular processes.

Even mild renal disease should be considered a major risk factor for cardiovascular complications after a myocardial infarction.

Each 10 unit reduction in the estimated GFR is associated with a 10% increase in the risk for death or nonfatal adverse cardiovascular outcomes.

Unrecognized renal insufficiency is a common process with acute coronary syndrome, affecting almost 1/5 of patients.

Patients with normal serum creatinine undergoing primary percutaneous coronary intervention, up to 30% will be found to have significant renal dysfunction.

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