Rash on palms and soles

1. Coxsackie (hand Foot & Mouth) Vesicular lesions on a reddened base on hands , feet and buttocks. It typically includes small, red spots or blisters.

2. Rocky Mountain Spotted Fever 

Most often the rash begins as small, flat, pink, non-itchy macules on the wrists, forearms, and ankles. 

The rash involves the palms or soles in as many as 80 percent of the patients. 

3. Syphilis secondary- may have skin rashes and/or sores in mouth, vagina, or anus.  

The rash appears as rough, red, or reddish brown spots on the palms of the hands and/or the bottoms of the feet. 

4. Janeway Lesions of bacterial endocarditis are non-tender, small erythematous or hemorrhagic macular or nodular lesions on the palms or soles only a few millimeters in diameter that are indicative of infective endocarditis. 

Janeway lesions are cutaneous evidence of septic emboli

5. Kawasaki Disease In the acute phase of the disease, changes in the peripheral extremities can include erythema of the palms and soles, which is often striking with sharp demarcation and often accompanied by painful, brawny edema of the dorsa of the hands or feet. 

7. Toxic Shock Syndrome The staphylococcal TSS rash is more likely to desquamate, particularly on the palms and soles, between 3 and 7 days after onset.

8. Reactive Arthritis A small percentage of men and women develop small hard nodules called keratoderma blennorrhagicum on the soles of the feet and, less commonly, on the palms of the hands or elsewhere

9. Meningococcemia Petechiae that do not disappear when pressure is applied to the skin) occur in 50-75% of cases

10. Contact Dermatitis: can lead to a red, itchy rash on the palms and soles.

11. Dyshidrotic Eczema: This type of eczema affects the hands and feet, causing small, itchy blisters on the palms and soles.

12. Psoriasis: It manifests as red, scaly patches with silvery scales.

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