Group of abnormalities with resistance to parathyroid hormone.

Most cases due the mutations that inactivate the signal transducing protein Gs-α.

Patients may be resistant only to parathyroid hormone or to other hormones including TSH, FSH, and LH.

Albright’s hereditary osteodystrophy which includes short stature, shortened fourth and fifth metacarpals and metatarsals, obesity, retardation, subcutaneous calcifications, café au lait spots, multiple hormone resistance, hypocalcemia, hyperphosphatemia, elevated parathyroid levels and hereditary pattern most common form of syndrome.

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