Analysis of all expressed proteins in a biological system.
Proteomics : indentify and study an entire set of expressed proteins in the human body.
These sets are called proteomes, and alter over time and depict current health conditions.
Proteins mediate phenotypic effects of genomic sequence, and many environmental factors.
proteins reflect ongoing, biological processes, and can supplement information regarding health status and disease risk.
Large scale measurements of protein levels are available.
Uses mass spectroscopy to analyze proteins and their modified forms.
Two dimensional gel electrophoresis can separate, fractionate, and atomize proteins extracted from biological samples.
Proteins change significantly depending on conditions.
Uses fresh frozen tissue and LASER assisted desorption to analyze spectrographically proteins by mass and charge ratio from location within the tissue specimen.
Can analyze plasma and serum specimens and compare protein expression profiles.
Estimated one and a half million proteins in the human body.
Helps identify protein peak patterns in determining prognosis in diseases.
The proteome is composed of subproteomes because each cell type has its on uniqueproteome.
Proteoforms make up a proteome and these proteoforms are the protein variants or forms that are produced by a genome.
Genes can create an assortment of proteins with subtle differences such as a gene expressing liver, brain kidney or hematopoietic system creating all different proteoforms in the proteome.
It is estimated that the human genome in encodes 19,750 proteins.
61,770 proteoforms have been identified: estimated 50 to 100,000,000 unique proteo forms exist.
Proteoform based assays can determine the species of infectious bacteria in patients and can identify proteinopathies such as Alzheimer’s disease and Parkinson’s disease.