Plays a role in the development of numerous disorders..
Misfolded proteins are central in the pathophysiology of Huntington’s disease, Parkinson’s disease, and Alzheimer’s disease.
Misfolded proteins play a role in the pathophysiology of heart diseases such as hypertrophy, dilated and ischemic cardiomyopathies.
Misfolded proteins may contribute to heart failure, as cardiomyocyte function depends on a critical balance between protein synthesis, protein folding, and protein turnover.
Newly synthesized translated proteins are associated with the molecular chaperones,which are specialized proteins that stabilize and fold proteins.
There are several classes of chaperones and folding enzymes that react with unfolded nascent proteins to minimize aggregation.