Promoter methylation

An epigenetic mechanism to regulate the expression of the gene.

Hypermethylation is associated with a silencing of the promoter and therefore reduced gene expression.

Hypomethylation leads to increased gene transcription.

About 25% of all triple negative breast cancers and 10 to 20% of high-grade serous ovarian cancers harbor BRCA 1 promoter methylation.

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