Primary effusion lymphoma

Aggressive and rare lymphoma occurring in patients with HIV and severe immunodeficiency.

Accounts for approximately 4% of HIV associated non-Hodgkin’s lymphomas.

Has been reported in recipients of solid organ transplants.

Has been reportedly elderly patients in the absence of immunodeficiencies.

Human herpes virus-8 viral genomes found in virtually all cases.

A subtype of B cell non-Hodgkin’s lymphoma characterized by lymphomatous effusions within the pleura, peritoneum, and pericardium.

Extracavitary tumors are rare.

Histologically cells appear as large immunoblastic or plasmablastic cells and range to cells with more anaplastic appearance.

Usually express CD45 and lack pan-B-cell markers.

Frequently express activation and terminally differentiated B cell related markers CD30, CD 38 HLA-DR, IRF4and CD138.

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