Pregnancy associated plasma protein

Pregnancy-associated plasma protein A

Pappalysin-1 also known as pregnancy-associated plasma protein A is a protein that in humans is encoded by the PAPPA gene.

Pappalysin-1 is used in screening tests for Down syndrome.

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs).

Involved in local proliferative processes such as wound healing and bone remodeling.

Low plasma levels been suggested as a biochemical marker for pregnancies with aneuploid fetuses.

Low levels may be seen in prenatal screening for Down syndrome, predict issues with the placenta, resulting in adverse complications such as intrauterine growth restriction, preeclampsia, placental abruption, premature birth, or fetal death.

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