An antibiotic with a high affinity for endotoxin.
When bound and immobilized to polystyrene fibers can be used as a hem perfusion device that can bind endotoxin and int2242upt the biological cascade of sepsis.
Hemodialysis device added to conventional therapy can improve hemodynamics and organ dysfunction and reduces 28 day mortality in a targeted population with severe sepsis and or septic shock from gram negative infections (Early Use of Polymyxin B Hemoperfusion in Abdominal Sepsis).