Plummer-Vinson syndrome

Esophageal webs, dysphagia and iron deficiency anemia.

Associated with other causes of iron deficiency.

Associated with increased incidence of post cricoid carcinoma.

About 90% of women with a the mean age at diagnosis of 47 years.

Range at diagnosis of ranges 20 to 80 years.

Associated with an increased risk of squamous cell carcinoma of the pharynx and esophagus, occurring in 3-15% of patients.

Iron supplementation is the main treatment.

Esophageal webs can be endoscopically dilated if dysphasia persists despite iron supplementation.

Annual upper gastrointestinal endoscopy is recommended to detect neoplastic lesions.

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