Platinum analogues

Used to treat a wide range of solid tumors: ovarian, head and neck, lung gastrointestinal and bladder cancers.

Atypical alkylating agents.

Work by binding to DNA, interfering with replication and transcription of cells.

Results in single-strand and sometimes double-strand breaks that the cell must repair before DNA can be replicated.

Homoloous recombination which requires intact BRCA protein can repair such breaks.

Cancers associated with BRCA mutation are sensitive to platinum analogues.

Carboplatin more likely to cause hematologic toxicity.

Toxicities of oxaliplatin fall between cisplatin and carboplatin.

Leave a Reply

Your email address will not be published. Required fields are marked *