Plays a role in intra- and extravascular fibrinolysis, wound healing, cell migration, angiogenesis, and embryogenesis.

Synthesized in the liver.

Cornea is a site of extrahepatic production.

Inherited deficiency disease divided into two types: type I, true deficiency and type II dysplasminogenemia.

Type 1 deficiency rare inflammatory disease with mucous membrane abnormalities of ligneous conjunctivitis, ligneous gingivitis, otitis media, ligneous bronchitis and gastrointestinal and female genital involvement.

Circulates in the plasma until in injury occurs.

Activators consist of endogenous and exogenous groups.

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