Plasminogen activator inhibitor-1 (PAI-1)

Primary physiologic inhibitor of plasminogen activation and regulates endogenous fibrinolytic activity and resistance to thrombolysis.

In tissue impairs cellular migration and matrix degradation following injury.

May contribute to development of thrombosis and fibrosis after tissue injury by chemicals or ionization.

A diagnostic marker and predictor of the severity of hepatic veno-occlusive disease.

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