Derived from enzymatic breakdown of its inactive circulating precursor plasminogen.

Limits the size of the final clot in the clotting cascade.

Principal protease of the fibrinolysis pathway.

Derived by breakdown of plasminogen by factor XII dependent pathway or by plasminogen activators.

Urokinase like plasminogen activator is present in plasma an other tissues and is able to activate plasminogen in the fluid phase.

Converts inactive pro-urokinase to active agent creating an amplification loop.

Most important plasminogen activator is tissue type plasminogen activator (t-PA).

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