Phosphatidylinositol 3-kinase (PIK3)

Plays an important role in many disease states..

Plays an integral role in translating extra cellular growth signals into the intracellular actions that facilitate growth by coupling macromolecule biosynthesis with the initiation of cell cycle progression.

A group of kinases that can be divided into three classes on the basis of substrate preference.

Class I PI3Ks are activated by insulin and other growth factors and are the most directly connected to cancer cell growth.

Approximately 40% of patients HR positive breast cancer harbor PIK3CA mutation, which leads to a relative resistance to endocrine therapy.

PIK3CA mutation also leads to estrogen independent growth of HR positive breast cancer through hyperactivation of the PI3K pathway.

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