Pelger-Huet anomaly


Inherited bi-lobed neutrophil which is benign and associated with coarse nuclear chromatin and without functional defects.

Heterozygote expression of an autosomal dominant disorder found in 1 in 6000 births.

Pseudo Pelger-Huet anomaly reflects acquired changes seen in myelodysplastic disorders, myeloproliferative disease, acute leukemia, drugs, and rarely acute infections.

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