Study that involves basic science and clinical practice devoted to studying the structural and functional changes in cells, tissues and organs that underlie disease.

Utilizing morphologic, molecular, immunologic and microbiologic techniques to explain signs and symptoms of disease and provides basis for clinical and therapeutic care.

Four aspects of disease process which are the core of pathology and include the etiology, pathogenesis, morphologic changes and clinical significance.

Etiology divided into intrinsic, or genetic, and acquired which includes infectious, chemical, physical and nutritional causes.

Pathogenesis refers to the events that occur in response of cells and tissues to the etiological agents from the initial stimulus to the end expression of the disease process.

Morphological changes refer to structural alterations in cells or tissues that are characteristic of the disease or are diagnostic of the disease.

Second pathologic review for breast cancer lesions results in discordance between 1.4%-10.4%.

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