Pappenheimer bodies



A type of inclusion body formed by phagosomes that have engulfed excessive amounts of iron.

Dense, blue-purple granules within the red blood cell.

Usually only one or two bodies are noted and they are located in the cell’s periphery.

Seen in sideroblastic anemia, hemolytic anemia, and sickle cell disease.

Visible with a Wright and/or Giemsa stains.

Prussian Blue stain confirms granules are non-heme iron.

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