Palifermin (Kepivance)

Truncated recombinant form of human keratinocyte growth factor to decrease incidence and duration of oral mucositis induced by myelotoxic treatment during hematopoietic stem cell transplantation.

A 28 kd member of fibroblast growth factor family with epithelial cell proliferation properties.

Keratinocyte growth factor, a fibroblast growth factor, exerts cyto-protective effects on epithelial cells.

Alleviates oral mucositis in patients treated with fractionated total right irradiation and high-dose chemotherapy for hematologic malignancies.

Decrease his oral mucositis, dysphagia, and xerostomia in patients with hyperfractionated radiation and concomitant chemotherapy for head and neck cancer.

Reduces the recurrence of severe oral mucositis in patients with head and neck cancer undergoing postoperative radio-chemotherapy (Henke M et al).

Leave a Reply

Your email address will not be published. Required fields are marked *