Alkylating agent
Altretamine or Hexalen 50mg caps 260mg/m² daily in four divided doses for either 14 or 21 consecutive days in a 28 day cycle
Carboplatin 10mg/mL soln for IV infusion
300mg/m² on Day 1 every 4 weeks for 6 cycles, recurrent ovarian cancer: 360mg/m² on Day 1 every 4 weeks
Cisplatin 1mg/mL soln for IV infusion after dilution
100mg/m² once every 4 weeks
Cyclophosphamide 25mg, 50mg tabs 1–5mg/kg/day
Cyclophosphamide 500mg, 1g, 2g pwd for inj after reconstitution
40–50mg/kg in divided doses over 2–5 days or 10–15mg/kg every 7–10 days or 3–5mg/kg twice weekly
Melphalan Alkeran 2mg scored tabs
-0.2mg/kg/day for 5 days; repeat every 4–5 weeks
Thiotepa 15mg pwd for IV, intravesical, or intracavitary administration after reconstitution
0.3–0.4mg/kg IV once every 1–4 weeks
Doxorubicin Adriamycin 10mg, 20mg, 50mg pwd for IV inj after reconstitution
Monotherapy: 60–75mg/m² every 21 days
Combination therapy: 40–60mg/m² every 21 to 28 days
Adriamycin Solution
Doxorubicin (liposomal) Doxil 2mg/mL dispersion for IV infusion after dilution
50mg/m² once every 4 weeks
Antimetabolite
Gemcitabine Gemzar 200mg, 1g pwd for IV infusion after reconstitution
1000mg/m² on Days 1 and 8 of each 21 day cycle
Hydroxyurea Hydrea
500mg caps Intermittant therapy: 80mg/kg as single dose every 3rd day
Continuous therapy: 20–30mg/kg/day as single dose
Antimicrotubule agents
Paclitaxel Taxol 6mg/mL soln for IV administration after dilution
175mg/m² over 3 hours or 135mg/m2 over 24 hours; repeat every 3 weeks
Topoisomerase inhibitor
Topotecan Hycamptin 4mg pwd for IV infusion after reconstitution and dilution
1.5mg/m² daily for 5 consecutive days starting on Day 1 of a 21-day cycle