Opsoclonus-myoclonus syndrome

An autoimmune neurological disorder.

Characterized by an unsteady and trembling gait, myoclonus, and opsoclonus.

Patients have difficulty speaking or an inability to speak.

Patients may have a decrease in muscle tone, lethargy, irritability, and malaise.

The prognosis for opsoclonus myoclonus varies depending on the symptoms and the presence and treatment of tumors. With treatment of the underlying cause of the disorder, there may be an improvement of symptoms. The symptoms sometimes recur without warning. Generally the disorder is not fatal.

Opsoclonus is nystagmus and myoclonus refers to involuntary muscle twitching.

Antibodies associated with a viral infections and neuroblastoma

Occurs most often in children.

4% of children with neuroblastoma develop opsoclonus-myoclonus syndrome.

Any child who has OMS should be evaluated for the presence of neuroblastoma.

Treatment includes surgical resection of the neuroblastoma.

Treatments include: corticosteroid therapy, intravenous gamma globulins. Imuran, chemotherapy with methotrexate, cyclophosphamide, apheresis, and immunoadsorption.

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