Initially utilized as treatment for premature ovarian insufficiency and more commonly for treatment of age related diminished reserve.
Perinatal risk among older women undergoing donor ooocyte in vitro fertilization reflects donor rather than recipient age.
Complication rate 0.7% and include ovarian hyperstimulation syndrome, hemorrhage and adverse anesthesia effects.
Oocyte cryopreservation is an effective option that allows women to achieve pregnancy at old ages.
Ovaries are stimulated for 8 to 14 days with injectable gonadotropins to recruit multiple mature follicles.
Oocytes are surgically retrieved by transvaginal needle guided aspiration and rapidly cryopreserved.
Subsequently oocytes can be thawed and fertilized using IVF.
There is no known upper limit for the length of time that oocytes can remain cryopreserved.