Non-Hodgkin’s lymphoma classification

Lymphoma – B cell neoplasms B cell disorders WHO classification of B cell lymphoid neoplasms




Precursor B cell neoplasms: ● Precursor B lymphoblastic leukemia/lymphoma

Mature (peripheral) B cell neoplasms: ● Chronic lymphocytic leukemia/small lymphocytic lymphoma ● B cell prolymphocytic leukemia ● Splenic marginal zone lymphoma ● Hairy cell leukemia ● Splenic lymphoma/leukemia, unclassifiable


     Splenic diffuse red pulp small B-cell lymphoma*
     Hairy cell leukemia-variant*

● Lymphoplasmacytic lymphoma


     Waldenstrom macroglobulinemia

● Heavy chain diseases (alpha, gamma, mu) ● Plasma cell myeloma ● Solitary plasmacytoma of bone ● Extraosseous plasmacytoma ● Extranodal marginal zone B-cell lymphoma of muocsa associated lymphoid tissue (MALT lymphoma) ● Nodal marginal zone B-cell lymphoma (MZL)


     Pediatric type nodal MZL

● Follicular lymphoma


     Pediatric type follicular lymphoma

● Primary cutaneous follicle center lymphoma ● Mantle cell lymphoma ● Diffuse large B cell lymphoma (DLBCL), not otherwise specified


     T cell/histiocyte rich large B-cell lymphoma
     DLBCL associated with chronic inflammation
     Epstein-Barr virus (EBV)+ DLBCL of the elderly

● Lymphomatoid granulomatosis ● Primary mediastinal (thymic) large B cell lymphoma ● Intravascular large B cell lymphoma ● Primary cutaneous DLBCL, leg type ● ALK+ large B-cell lymphoma ● Plasmablastic lymphoma ● Primary effusion lymphoma ● Large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease ● Burkitt lymphoma ● B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma ● B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma

Mature T-and natural killer-cell neoplasms.

T-celll prolymphocytic leukemia

T-cell large granular lymphocytic leukemia

Adult T-cellll leukemia/lymphoma

Extranodal natural killer-T cell lymphoma, nasal type

Enteropathy-type T-cell lymphoma

Hepatosplenic T-cell lymphoma

Subcutaneous panniculitis like T-cell lymphoma

Mycoses fungoides

Sezary syndrome


Primary cutaneous cd 30 positive T cell lymphoproliferative disorders

Peripheral T cell lymphoma

Angioimmunoblastic T-cell lymphoma

Anaplastic large cell lymphoma, anaplastic lymphoma kinase-positive

Immuno deficiency associated lymphoproliferative disorders

Lymphoproliferative disease is associated with primary immune disorders

Lymphoma associated with human immunodeficiency virus infection

Post transplant lymphoproliferative disorders

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