Lymphoma – B cell neoplasms B cell disorders WHO classification of B cell lymphoid neoplasms
Classification
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Precursor B cell neoplasms: ● Precursor B lymphoblastic leukemia/lymphoma
Mature (peripheral) B cell neoplasms: ● Chronic lymphocytic leukemia/small lymphocytic lymphoma ● B cell prolymphocytic leukemia ● Splenic marginal zone lymphoma ● Hairy cell leukemia ● Splenic lymphoma/leukemia, unclassifiable
Splenic diffuse red pulp small B-cell lymphoma*
Hairy cell leukemia-variant*
● Lymphoplasmacytic lymphoma
Waldenstrom macroglobulinemia
● Heavy chain diseases (alpha, gamma, mu) ● Plasma cell myeloma ● Solitary plasmacytoma of bone ● Extraosseous plasmacytoma ● Extranodal marginal zone B-cell lymphoma of muocsa associated lymphoid tissue (MALT lymphoma) ● Nodal marginal zone B-cell lymphoma (MZL)
Pediatric type nodal MZL
● Follicular lymphoma
Pediatric type follicular lymphoma
● Primary cutaneous follicle center lymphoma ● Mantle cell lymphoma ● Diffuse large B cell lymphoma (DLBCL), not otherwise specified
T cell/histiocyte rich large B-cell lymphoma
DLBCL associated with chronic inflammation
Epstein-Barr virus (EBV)+ DLBCL of the elderly
● Lymphomatoid granulomatosis ● Primary mediastinal (thymic) large B cell lymphoma ● Intravascular large B cell lymphoma ● Primary cutaneous DLBCL, leg type ● ALK+ large B-cell lymphoma ● Plasmablastic lymphoma ● Primary effusion lymphoma ● Large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease ● Burkitt lymphoma ● B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma ● B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma
Mature T-and natural killer-cell neoplasms.
T-celll prolymphocytic leukemia
T-cell large granular lymphocytic leukemia
Adult T-cellll leukemia/lymphoma
Extranodal natural killer-T cell lymphoma, nasal type
Enteropathy-type T-cell lymphoma
Hepatosplenic T-cell lymphoma
Subcutaneous panniculitis like T-cell lymphoma
Mycoses fungoides
Sezary syndrome
Primary cutaneous cd 30 positive T cell lymphoproliferative disorders
Peripheral T cell lymphoma
Angioimmunoblastic T-cell lymphoma
Anaplastic large cell lymphoma, anaplastic lymphoma kinase-positive
Immuno deficiency associated lymphoproliferative disorders
Lymphoproliferative disease is associated with primary immune disorders
Lymphoma associated with human immunodeficiency virus infection
Post transplant lymphoproliferative disorders