NFKB1
Nuclear factor NF-kappa-B subunit is a protein that in humans is encoded by the NFKB1 gene.
Gene location Chromosome 4
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein.
The 105 kD protein is a Rel protein-specific transcription inhibitor.
The 50 kD protein is a DNA binding subunit of the NF-kappaB (NF-κB) protein complex.
NF-κB is a transcription factor that is activated by various stimuli including: cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products.
Activated NF-κB translocates into the nucleus and stimulates the expression of a variety of genes.
These genes are involved in a wide variety of biological functions.
There are over 200 known genes that are targets of NF-κB.
The inappropriate activation of NF-κB is associated with a number of inflammatory diseases.
The persistent inhibition of NF-κB leads to inappropriate immune cell development or delayed cell growth.