MEK

MEK

 

See ((MEK inhibitors))

 

 

 

Mitogen-activated protein kinase 1, also known as MEK1 (MAP2K1)

 

 

It is a protein kinase down stream from RAS  and RAF in the signaling cascade that plays in important role in cellular proliferation and differentiation.

 

 

MAP2K1 mutations are rare and represent approximately 1-2% of patients with colorectal cancer.

 

 

MAP2K1  aberrations was contributed to carcinogenesis.

 

 

MAP2K1 in non-small cell lung cancer are associated with the worse prognosis.

 

 

MAP2K1 mutations may respond to MEK inhibitors as seen in histiocytic sarcoma, serous ovarian cancer and Langerhans cell histiocytosis.