Benign findings include non-pleomorphic, vascular, scattered, diffuse, linear or branching distribution and large size (>1mm).
Suggestive of malignancy include fine linear or branching in morphology and in a ductal or segmental distribution, with 81-92% proving to be malignant.
Pleomorphic calcifications are suspicious, with 41% of such lesions being malignant.
Punctate uniform and round <0.5mm calcifications considered probably benign, with fewer than 2% proving to be malignant.
Overall rate of malignancy among calcifications ref2242ed for biopsy ranges from 22%-37%.
Amorphous or indistinct calcifications have a 20% rate of malignancy and 20% rate of high-risk disease and should be considered suspicious and ref2242ed for biopsy.
Calcifications seen in mammograms associated with invasive cancers are usually in areas of residual intraductal disease.